DEADPOOL

Deadpool is a Marvel comic book character with whom I am not familiar in the least (since I only read sporadic comics in the '70s and early '80s and not much after, and encountered him for the first time as Wade Wilson in the Wolverine Origins movie).  In a gaming capacity I first met Deadpool in Marvel vs Capcom 3 - Fate Of Two Worlds.

This unstable mercenary and genetically mutated nut made his first comic book appearance in the early-'90s, and has not exactly reached the stature of other comic book heroes like Super-, Bat-, Iron-, Spider-Man and others (yes I know some of them are DC).  But, those A-grade characters need to get some rest and let this wise-cracking anti-hero (who converses with a few voices in is bent head) tear it up a bit (with swords, a whole bunch of guns, explosives and the ability to teleport). 

The product of a radical experimental military enhancement method (the Weapon X programme, that also created Wolverine), Deadpool has intense regenerative abilities. 
Sometimes a goof, mostly a jerk-off, in the Campaign mode you're taken on a crazy and violent trip where Deadpool pitches a ridiculous video game starring himself, and the line between the game and this unreality merge when he takes a job to knock off the studio boss.  But, Mister Sinister happens to be hatching a plot. 
Other Marvel characters you can expect to encounter include Wolverine, Domino, Psylocke, Rogue, Cable, and Death.  

Running on the Unreal engine, the fighting controls of this over-the-top shoot- & beat-'em-up are swift and smooth, and carries an 18 restriction due to some very violent and bloody content, and a bunch of swearing and opportunities to be crude with situations to choose between something mundane or more radical (like taking a dump in the toilet and inflating his blow-up doll!). 

For Challenges you'll need to be logged into the PlayStation network.  

A - Multiple Playing Prospects
B - Can be taken for another Run
C - Once Should Suffice